| 产品中文名称 | 重组人白介素10（IL-10） |
| 产品英文名称 | Human IL-10 Protein |
| 产品别名 | CSIF; IL10A; TGIF; Cytokine Synthesis Inhibitory Factor; IL10; IL-10; IL 10 |
| 产品描述 | IL-10 is an anti-inflammatory cytokine that belongs to the IL-10 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells, and other cell types, while it is produced primarily by monocytes and to a lesser extent by lymphocytes. IL-10 is mainly expressed in monocytes and Type 2 T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and also in a certain subset of activated T cells and B cells. IL-10 has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. The importance of interleukin 10 for counteracting excessive immunity in the human body is revealed by the fact that patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant IL-10. IL-10 inhibits the synthesis of some cytokines, including IFN-gamma, IL-2, IL-3, TNF, and GM-CSF produced by activated macrophages and by helper T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen-presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production. |
| 标签 | 无标签 |
| 表达宿主 | 大肠杆菌 |
| 种属 | 人 |
| 序列 | 氨基酸序列来源于：人源IL 10 (Ser19-Asn178) (P22301) 表达的蛋白片段。 |
| 活性 | Testing in Progress |
| 蛋白长度 | 重组人 IL10由161个氨基酸组成，预测分子量为18.78 KD。 |
| 纯度 | > 97% ，使用SDS-PAGE检测 |
| 特点&优势 | 通过LAL法测定，每微克蛋白里内毒素含量<1.0 EU。 |
| 产品形式 | 冻干粉，冻干缓冲液为无菌的20 mM Tris，150 mM NaCl，pH 7.4。 |
| 基因ID | 3586 |
| 蛋白序列链接 | https://www.ncbi.nlm.nih.gov/protein/NP_000563.1,NP_001369553.1 |
| 使用中注意事项 | 开盖使用前，请先离心。本产品为冻干粉，推荐用该产品配套的Reconstitution Buffer进行复溶，且浓度不低于100 µg/mL。客户可根据后续的实验需求，进行进一步的稀释。 |
| 保存建议 | 冻干蛋白应在 -20°C 下保存 1 年。复溶后，在 2°C 至 8°C 下最多可保存 1 周。 在含有载体蛋白或稳定剂的缓冲液（0.1% HSA或者BSA）中进一步稀释后，分装的蛋白质应在 -20°C 或 -80°C 下保存 3-6 个月。避免反复冻融循环。 |
| 运输条件 | 冰袋运输（蓝冰） |
| 警告 | 本文列出的产品仅供研究使用，不适用于人类或临床诊断。我们产品所推荐应用，不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为，我们不承担任何责任。 |